Comprehensive updates on novel biologics, small molecule inhibitors, and treaty-to-target strategies for Crohn's disease and ulcerative colitis.
Crohn’s disease and ulcerative colitis, with detailed therapeutic algorithms.
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Coverage of state-of-the-art diagnostic and therapeutic techniques.
The 12th edition maintains the two-volume format familiar to its readership, organized anatomically and physiologically. However, a notable shift in this edition is the streamlined organization of sections to facilitate rapid information retrieval. The text is divided into distinct biological and clinical sections:
remains the gold-standard medical reference for gastroenterology and hepatology professionals worldwide. Released by Elsevier in December 2025, this fully updated two-volume masterwork continues a 50-year legacy of bridging basic science with cutting-edge clinical management. Led by a new generation of senior editors— Dr. Raymond T. Chung , Dr. David T. Rubin , and Dr. Mel Wilcox —the 12th edition delivers a modernized, global perspective on treating complex digestive and hepatic disorders. Core Specifications Overview
Hepatitis, cirrhosis, and metabolic liver disease.
remains the gold standard textbook for gastroenterologists, hepatologists, and internal medicine specialists worldwide. Published by Elsevier, this landmark reference work provides an unparalleled, comprehensive fusion of basic science, clinical pathophysiology, and evidence-based diagnostic and therapeutic strategies.
To enhance learning and retention, the 12th edition includes:
: Fully integrates the new nomenclature for Metabolic Dysfunction-Associated Steatotic Liver Disease ( MASLD ), replacing the historical term NAFLD.
A new chapter dedicated to the role of the gut microbiome in health and disease, plus integrated discussions on fecal microbiota transplantation (FMT) for C. difficile and emerging microbiome-based therapies.
The 12th edition maintains its foundational commitment to blending basic scientific principles with pragmatic, bedside clinical management. It is designed around a pathophysiological framework, ensuring clinicians do not merely memorize treatment algorithms but deeply understand the underlying mechanisms of disease.
The Golden Standard Returns: Exploring Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 12th Edition For over five decades, Sleisenger & Fordtran's Gastrointestinal and Liver Disease
For clinicians, institutional buyers, and trainees building a medical library, the physical and digital formats of this definitive reference balance immense depth with structural accessibility. Elsevier Science Health Science Publication Date December 10, 2025 Page Count 2,560 pages (Print Version) Format Options 2-Volume Hardcover Set & VitalSource eTextbook ISBN-13 978-0443116575 Key Accolade Selected as an Essential Purchase for Doody's Core Titles Critical Editorial Evolution